Fri. Jun 18th, 2021

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'Significant Effect Unlikely If Doses Mixed': Centre After UP Mix-Up

India currently produces around 8.5 crore vaccine doses per month (File)

New Delhi:

Significant adverse effects are “unlikely” if an individual’s second Covid vaccine dose is different from the first, the centre said Thursday afternoon, in response to controversy over a group of Uttar Pradesh villagers being given mixed doses at a government hospital in Siddharthnagar district.

“This should be looked into. We will have to wait for more scientific understanding… but even if two doses of two different vaccines are given, this should not be a cause of concern,” Dr VK Paul, the Chair of NEGVAC (National Expert Group on Vaccine Administration for COVID-19), said.

“Any significant adverse effect is unlikely… but we need more scrutiny,” he added.

Earlier this month 20 UP villagers were given Bharat Biotech’s Covaxin when they went for the mandatory second dose. They were administered Covishield on their first visit in early April.

“This is definitely an oversight. There are no instructions from the government to administer a cocktail of vaccines. I have asked for an explanation from those who are guilty. We will take whatever action is possible,” Sandeep Chaudhary, the district’s Chief Medical Officer, said.

Days before the UP mix-up a 72-year-old man in Maharashtra was also given two different vaccines; Dattatraya Waghmare, a resident of a village in Jalna district, said he got Covaxin on March 22 and Covishield on April 30.

Mr Waghmare’s son, Digambar, said his father developed minor complications after the second dose, such as mild fever, rashes in some parts of the body and anxiety attacks.

The effectiveness, or impact, of mixing vaccines is still a subject of global research.

Two weeks ago the preliminary results of a study that mixed doses was published in The Lancet.

People who got a first dose of the AstraZeneca vaccine (Covishield) and a second dose of Pfizer reported more short-lived side effects – most mild – researchers from Oxford University reported.

The study has yet to show, however, how well such a cocktail might defend against the virus.

The mix-up in Uttar Pradesh was not part of any study; at least one of the villagers told reporters nobody from the state’s health department had checked up on them.

“I found out later I had been administered Covaxin. A doctor told us something wrong happened,” Ram Surat, an elderly man, said, adding, “When I went for my second dose no one bothered to check anything. In place of Covishield I got Covaxin. It is scary. I am worried.”

Researchers and public health officials across the world are figuring out if mixing two vaccines can help low- and middle-income nations cope with the scarcity of doses, but there is still concern over possible side-effects and if the cocktail will actually protect people from the COVID-19 virus.

If it is possible to mix doses India is likely to be among several countries that will benefit; the national vaccination drive has slowed in recent weeks (coinciding with the devastating second wave of infections and deaths) over a shortage of doses.

At present domestic vaccine production is around 8.5 crore doses per month, of which 6.5 crore are Covishield and two crore are Covaxin. Both are two-dose vaccines, which means being able to mix doses will double, theoretically, the number of people that can be vaccinated in a month.

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