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Groundbreaking UK gene therapy offers hope after progress of three-year-old

Oliver Chu from California first person to have the one-off treatment for Hunter syndrome Doctors are cautiously optimistic about a groundbreaking gene therapy for children affected by a devastating inherited disorder after seeing positive results in the first boy to receive the treatment. Three-year-old Oliver Chu from California became the first patient to have the therapy nine months ago as part of a clinical trial run by researchers in Manchester. It is too early to call the therapy a success, but doctors are encouraged by his progress so far. Continue reading… Source link

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Ukraine makes significant changes to US ‘peace plan’, sources say

Some of Russia’s maximalist demands have been removed from original 28-point proposal, it is understood Europe live – latest updates Ukraine has significantly amended the US “peace plan” to end the conflict, removing some of Russia’s maximalist demands, people familiar with the negotiations said, as European leaders warned on Monday that no deal could be reached quickly. Volodymyr Zelenskyy may meet Donald Trump in the White House later this week, they indicated, amid a flurry of calls between Kyiv and Washington. Ukraine is also pressing for Europe to be involved in the talks. Continue reading… Source link

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UK rejects Nigerian request to deport former politican jailed for organ trafficking

Ike Ekweremadu serving prison sentence after being found guilty of conspiring to exploit a man for his kidney The UK government has rejected a request by Nigeria to deport a former senior Nigerian politician convicted of organ trafficking. Ike Ekweremadu, 63, a former deputy president of the Nigerian senate and ally of the former president Goodluck Jonathan, is serving a sentence of nine years and eight months after being found guilty in 2023 of conspiring to exploit a man for his kidney. Continue reading… Source link

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US woman behind Slender Man stabbing caught after escaping from group home

Police had issued alert after Morgan Geyser cut off monitoring bracelet, and was reportedly located at a truck stop The Wisconsin woman who admitted to repeatedly stabbing a sixth-grade classmate to delight the fictional online horror character Slender Man in 2014 has been caught after authorities said she cut off a monitoring bracelet and left her group home. Morgan Geyser, 23, was found in Posen, Illinois, on Sunday evening, authorities said. Police in Madison, Wisconsin, had issued an alert for Geyser earlier in the day, saying she had last been seen with an adult acquaintance on Saturday evening. The…

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MPs to question key BBC figures amid editorial crises – latest updates

Michael Prescott, author of leaked memo, chair Samir Shah and board members Robbie Gibb and Caroline Thomson to appear at select committee The BBC has been in crisis since the sudden resignation of its director general, Tim Davie, and the head of news, Deborah Turness. Their decision shocked many in New Broadcasting House, but what emerged in the hours after their departure was talk of a rightwing “coup”, board splits and crippling delays. Continue reading… Source link

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Not-for-profit disability services are closing due to untenably low price caps, NDIS architect warns

Providers report a median operating loss of nearly 4% in the last financial year – with losses totalling about 12% over five years Get our breaking news email, free app or daily news podcast Not-for-profit disability services that support some of the most vulnerable Australians are being forced to close and exit the national disability insurance scheme because of untenably low price caps for NDIS services, one of the architects of the scheme has warned. “For some years, many of us in the sector have been telling the National Disability Insurance Agency that flaws in their pricing are contributing…

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Northamptonshire police officers face misconduct hearing over Harshita Brella case

IOPC said four officers may potentially have breached standards in handling abuse claims by Brella, 24, found dead last year Four Northamptonshire police officers are facing misconduct hearings due to their handling of abuse claims by Harshita Brella, who was found dead last year. Brella, a 24-year-old from Corby, was found dead in a car boot in Ilford, east London, on 14 November 2024. It is suspected she was strangled in Corby, Northamptonshire on 10 November. Continue reading… Source link

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UK wildfires devastated more areas in 2025 than at any time since records began, figures show

Firefighters call for long-term investment and say UK is dangerously underprepared as climate crisis worsens Wildfires have devastated more moorland, forests and fields in the UK this year than at any time since records began, putting huge pressure on the country’s fire service, figures show. The Global Wildfire Information System estimates that by November, wildfires had burned 47,026 hectares (116,204 acres) in 2025 in the UK – the largest area in any year since monitoring began in 2012, and more than double the area burned in the record-breaking summer of 2022. Continue reading… Source link

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Ethiopian volcano erupts for first time in 12,000 years

Ash clouds from Hayli Gubbi volcano have drifted over Yemen, Oman, India and northern Pakistan A volcano in Ethiopia’s north-eastern region has erupted for the first time in nearly 12,000 years, sending thick plumes of smoke up to nine miles (14km) into the sky, according to the Toulouse Volcanic Ash Advisory Centre (VAAC). The Hayli Gubbi volcano, located in Ethiopia’s Afar region about 500 miles north-east of Addis Ababa near the Eritrean border, erupted on Sunday for several hours. Continue reading… Source link

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Diaries, artworks and more to be auctioned from Marianne Faithfull’s personal belongings

Late singer’s personal effects up for sale including a trunk gifted to her by Carrie Fisher, and artworks by Anita Pallenberg and Marlene Dumas Diaries and a gift from actor Carrie Fisher are among the personal items from Marianne Faithfull that are going up for auction in London. The musician died in January aged 78, leaving behind a cache of fascinating portraits, photographs and ephemera from a glamorous, sometimes troubled life. “Each piece tells a story and reflects her spirit and inimitable taste,” her son Nicholas Dunbar said. “It is time now for these belongings to find new homes…

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Trump DoJ’s focus on Maga goals harms other investigations, experts warn

Exodus of lawyers under Trump weakens department’s capacity in civil rights, national security and other areas Donald Trump’s weaponization of the US department of justice to focus on retribution against political foes, on fulfilling Maga goals and on ranting pardons for allies has seen thousands of lawyers depart or be fired and weakened investigations in civil rights, national security and other areas, say ex-prosecutors and legal experts. Data compiled by the nonpartisan Justice Connection showed that overall DoJ employment has dropped by about 5,500 lawyers and non-lawyers who have left since Trump took office. That included people who were…

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Jimmy Cliff, Jamaican reggae singer, actor and cultural icon, dies aged 81

Star of The Harder They Come had hits including You Can Get It If You Really Want and I Can See Clearly Now Jimmy Cliff, the singer and actor whose mellifluous voice helped to turn reggae into a global phenomenon, has died aged 81. A message from his wife Latifa Chambers on Instagram reads: “It’s with profound sadness that I share that my husband, Jimmy Cliff, has crossed over due to a seizure followed by pneumonia. I am thankful for his family, friends, fellow artists and coworkers who have shared his journey with him. To all his fans around…

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Trump touts cheap groceries ahead of Thanksgiving. The reality is a mixed plate

President looks to Walmart’s promotion as proof he lowered cost of living. But holiday prices are volatile, economists say If you feel like the price of Thanksgiving this year is more expensive to gobble up, you’re not alone. Amid widening concerns about the rising cost of living, polls show consumers are increasingly worried about inflation. Economists say the picture for holiday food prices this year is more mixed – prices are volatile and depend largely on how families shop around for their feast. Continue reading… Source link

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Spain’s attorney general quits after guilty verdict for leaking confidential information

Blow to leftist coalition government of PM Pedro Sánchez, who appointed Álvaro García Ortiz in 2022 Spain’s chief prosecutor has announced his resignation after the supreme court found him guilty last week of leaking confidential information in a case involving a leading opposition figure’s partner. The unprecedented case is a blow to the leftist coalition government of the prime minister, Pedro Sánchez, who appointed Álvaro García Ortiz in 2022 and has defended his innocence repeatedly. Continue reading… Source link

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‘How could that happen?’: footage of Sea World helicopters in deadly mid-air collision shown at inquest

Survivor tells how she was trapped under ‘hot machinery’ in the wreckage after the choppers crashed over the Gold Coast Follow our Australia news live blog for latest updates Get our breaking news email, free app or daily news podcast A woman has given a harrowing account of how she was trapped under “hot machinery” after the Sea World helicopter she was travelling in collided with another over the Gold Coast, killing four people. Giving evidence on Monday at the start of the inquest into one of Australia’s worst air disasters, Winnie De Silva relived the moment the two…

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Teenager dies after being stabbed in thigh at reserve in Sydney’s north-west

A 17-year-old boy suffering stab wounds was treated by NSW paramedics but died at the scene Get our breaking news email, free app or daily news podcast A 15-year-old young person is under arrest after a teenage boy was fatally stabbed in the leg in Sydney’s north-west on Monday afternoon. Speaking to the media on Monday evening, Supt Naomi Moore said the 17-year-old was stabbed in the thigh and the alleged offender then fled. The 17-year-old was treated by New South Wales paramedics but died at the scene. Continue reading… Source link

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Ukraine working with US on ‘compromises that strengthen us’, says Zelenskyy – Europe live

US and Ukraine say they have ‘updated framework’ for peace plan after weekend talks in Geneva Over in Brussels, EU ministers are meeting for discussions on trade, including specifically with the US, with two senior US representatives – trade representative Jamieson Greer and treasury secretary Howard Lutnick – joining them for lunch. EU trade commissioner, Maroš Šefčovič, described his talks with US counterparts as “constructive,” even as he added that “more work lies ahead.” Continue reading… Source link

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Mining giant BHP drops latest bid to buy rival Anglo American

FTSE 100-listed miner forces Australian company to walk away from takeover after rebuffing second approach BHP has walked away from another attempt to take over rival miner Anglo American after it was again rebuffed, failing in a last-minute effort to disrupt the planned merger with Canadian mining business Teck Resources. The Australian mining company reportedly became interested in making another offer for FTSE 100-listed Anglo last week, more than a year after abandoning a £39bn attempt to buy the business. Continue reading… Source link

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Udo Kier, German actor who starred in 200 films spanning Lars von Trier to Ace Ventura, dies aged 81

Actor who appeared in My Own Private Idaho, Blade, Armageddon and Dogville, as well as Madonna music videos and video games, died on Sunday Udo Kier, the German actor who appeared in 275 roles across Hollywood and European cinema, including multiple films by Rainer Werner Fassbinder, Gus Van Sant and Lars von Trier, has died aged 81. Kier died on Sunday morning, his partner Delbert McBride told Variety. The actor died in hospital in Palm Springs, California, his friend the photographer Michael Childers announced on social media. No cause of death was given. Continue reading… Source link